ALWAYS by Faciem Meam, with Insolitus skincare. The line uses patented bioactive peptides, and active and complete growth factors. They state they “ use a patented delivery system called OREUM which consists of PLGA active spheres that penetrate the skin to the DERMIS and deliver 1 to 200 active principles. The rest of the competition does NOT use this system and for this reason their active principles DON´T penetrate the external layers of the skin and don´t reach the stem cells of the skin where they should perform/work/take action.” Best of all they reinvest most of the money from sales into research for rare,and ultra rare , diseases in children! I have been using the Eye Contour Repair and 24 Hour Crème. I love the results. So get Beautiful You Always, and everyday….